The Magpies boss is content with his summer's work and does not expect any departures in the next four days.
"I hope we don’t lose anyone, and we have no intention of doing that," said the former England manager, in quotes published by the Northern Echo.
"There’s a great determination from the club, to reiterate from two weeks ago, that we don’t need to sell.
"We don’t have to sell, we don’t want to sell, and we don’t want to lose any of our best players."
McClaren also suggested that further new arrivals were unlikely after a busy summer of activity, which has seen the likes of Florian Thauvin, Georginio Wijnaldum and Aleksandar Mitrovic make high-profile switches to Tyneside.
"We’ve wanted to bring players in, and we have done that with Thauvin. At this present moment, we are happy," he added.
While the Magpies have definitely improved the attacking threat within their squad over the last few months, there are still some areas of concern.
Central defence may prove an issue with Mike Williamson, Steven Taylor and Jamaal Lascelles all unconvincing back-ups for the ageing Fabricio Coloccini and the inexperienced Chancel Mbemba.
Beyond Daryl Janmaat, there are no real options at right-back, while Chieck Tiote’s erratic form will be a worry for the depth of cover in defensive midfield.
There is cause for optimism overall, however, and last week’s battling goalless draw at Old Trafford suggested a team fully committed to their manager’s methods and full of attacking menace, capable of troubling any team in the division.