The Spurs man could come up against a player he trained with during an earlier loan spell at the Toffees.
Dier revealed that his time spent on loan at Goodison Park in 2011 from Sporting saw him training with current Toffees star Ross Barkley, as well as few others that were in the first team squad then.
The defender, who has recently been named in the England Under-21 side, admitted that he had been impressed with his old side so far, with Roberto Martinez's men having picked up four points from three matches in the early stages of the Premier League.
The Toffees won their League Cup tie against Barnsley in less convincing fashion this week though, having to come back from 2-0 and 3-2 down to force extra time, a situation that wouldn't have been ideal for them ahead of the trip to White Hart Lane.
“Everton have been really good so far this season so it’ll be a tough game, but obviously we’re determined to take the points ourselves,” Dier told the Spurs site.
“There’s still a few players at Everton from the time I was there – I trained with their first team sometimes and got to know people like Ross Barkley. He’s been playing really well so it’ll be good to test ourselves against people like him.
“We’re extremely disappointed with how it’s gone in terms of our results so far. We’ve obviously conceded after going ahead in the last two games but we’re going to try our best not to let it happen again.”
Dier is just one of a number of Tottenham players who have this week bemoaned their results so far in the Premier League, but like the others, he seems determined to put things straight against the Toffees.
The Spurs man didn't feature while he was at Everton, but Dier has previously spoken about how the spell helped him become accommodated to the more physical nature of English football compared to the more technical focus he was used to back in Portugal.
This season he has been performing well in an unfamiliar defensive midfield position that may well have convinced Mauricio Pochettino not to dip into the transfer market to strengthen that position, and he could come up against Barkley directly on Saturday if the England international starts.