The Arsenal back-up centre-half struggled in the first half against Liverpool, with the Frenchman toying with removing him from the pitch.
With Per Mertesacker and Laurent Koscielny unavailable, the French manager was forced to partner the young Englishman with Gabriel in the heart of his rearguard.
The home side’s defence made a number of telling errors in the first half of the 0-0 draw, with Chambers in particular guilty of giving the ball away in dangerous areas and lucky not to be punished.
When asked if he was tempted to substitute the former Southampton youngster, Wenger admitted it was an option.
“You’re always tempted,” the former Monaco boss told the club’s official website.
“I wondered whether I needed offensive players on the pitch. I knew that the most important thing for us was to get to half-time at 0-0. We knew the second half would be different.
“Chambers and Gabriel do not have the experience of playing together, they’ve come in from one day into the next, but overall we didn’t concede.
“Petr Cech saved us two or three times in the first half. In the second half I think we should’ve won the game. We were a bit unlucky, we lacked a bit physically and collectively to finish what we started.”
Despite a shaky first half, Wenger praised Chambers for his attitude in bouncing back and putting in an improved showing after the interval.
“He responded well,” the Arsenal boss continued.
“It was important for him. You sit there and you wonder how far he can go without losing competitive confidence.
“In the second half he did well. He’s a good footballer and he will come out of that stronger, with the belief that when he had difficult moments he can come out of it stronger.”
Chambers was signed last summer from Southampton and initially looked like a versatile and accomplished young player, with Wenger using him at right-back, centre-back and in midfield on occasion.
However, since the emergence of Hector Bellerin at right-back and the signing of Gabriel, Chambers’ outings have been few and far between.
Arsenal missed the experience and combination of Mertesacker and Koscielny against the Reds and were lucky not be punished as Philippe Coutinho and Christian Benteke both went close to scoring.