The Reds will visit the Emirates Stadium on Monday, with the right-back tasked with nullifying the Chilean.
The Reds have won their first two games against Stoke and Bournemouth but are set to face a real test as they travel to take on the Gunners at the Emirates Stadium on Monday night in a mouthwatering early-season fixture.
Sanchez proved the difference in the North London outfit’s 2-1 away win over Crystal Palace last time out, with the Chilean deciding the game in his team’s favour.
Although having competed in the Copa America over the summer and having not had a full pre-season, the former Barcelona attacker looked very dangerous at Selhurst Park and will be a threat to Liverpool’s 100 per cent record.
Clyne will be the man tasked with trying to shackle the South American star and has admitted that he and his team will have their hands full with Sanchez.
"You look at all his movements, how he picks up the ball and receives it and how he takes on players and whether he comes inside or outside,” the England international told Sky Sports.
"He's a great player and he works hard so we're going to have to do a good job in stopping him.”
Clyne joined the Merseyside club from Southampton over the summer and has immediately slotted into Brendan Rodgers’ defence, which is yet to concede in the Premier League this season so far.
Sanchez is sure to test the Englishman however, with their personal battle potentially playing a key role in dictating the result.