Swansea earned an impressive 2-2 draw at Chelsea last week, while Newcastle also drew by the same scoreline with Southampton during their first league clash of the season on Tyneside.
But Merson feels the hosts will have too much for the visiting Magpies, singling out forward Bafetimbi Gomis as a 'real handful.'
The pundit did, however, praise Newcastle boss Steve McClaren and feels steady progression will be the order of the day at St James' Park.
Merson told Sky Sports: "Swansea were very good at Chelsea and Bafetimbi Gomis is a real handful. Yes, [Chelsea goalkeeper Thibaut] Courtois was sent off but you have to give Swansea so much credit.
"I like McClaren, he's a good coach and will make the players better. It will be steady progression for them this season but this one is Swansea's all over."
Many Newcastle followers such as Alan Shearer and Steve Watson expressed concern about the Tyneside outfit's defending after their 2-2 draw with Southampton.
And, considering Swansea's impressive display at Stamford Bridge, Merson may well be right in that the formbooks clearly tip the scale in the Swans' favour.
Can McClaren, though, who Merson rates, prove the formbooks wrong at the Liberty Stadium and guide the Magpies to a memorable result so early in their Premier League season?