Leighton Baines is set to miss more than three months of Everton's season after undergoing ankle surgery, according to the Liverpool Echo.
The Everton left-back suffered ligament damage in training last week, and having had surgery on the same ankle earlier this calendar year, he has now undergone a second operation in a bid to cure the issue.
Baines is now set to be out of action until November at the very earliest, meaning he could miss more than a dozen league matches, including the Merseyside derby against Liverpool, as well as five games for the Three Lions.
This leaves Everton head coach Roberto Martinez searching for a temporary replacement for the England international.
Reports have linked with the club with a loan move for former Manchester United defender Alex Buttner, according to the Daily Mail.
Meanwhile, Costa Rica international Bryan Oviedo has also been tipped to feature more regularly.
Of course, Luke Garbutt - who would have been a definite replacement for the England international - is unavailable for selection following his loan move to Championship outfit Fulham.
Leighton Baines made 31 league appearances for the Toffees last season, fashioning an impressive 70 key passes in the final third.
Meanwhile, he completed 84% of his attempts to find a teammate, while winning 54% of his tackles and 53% of his take ons.
Here is how Everton supporters reacted on Twitter to news of the Everton man's latest injury set-back.
Buttner being linked with us now Baines is out for 3mths. Wouldn't have him personally, didn't look good enough when he was at Man Utd...— Ghedin1878 (@Ghedin1878) August 14, 2015
I doubt we'll see Baines til the new year, Martinez always underplays injuries— John (@jd_efc) August 14, 2015
Baines out for 3 months little chance of them letting Stones leave now I would think....— domcfc-gate13 (@dorsetdom1905) August 14, 2015
Oviedo and Galloway should be the cover for Baines. What would we do with Buttner when Baines was back? #efc— Dan (@BlueDanEFC) August 14, 2015
Everton topping the injury league already. No club has more injuries. McGeady, Hibbert, Gibson, Besic, Piennar, Baines, Mirallas & Deulofeu.— Tony Scott (@Tony_Scott11) August 14, 2015
That baines guy like going on injury too much.— ★OLAMILEKAN MUFC★ (@Wasgan) August 14, 2015
So Baines out 'till Nov/Dec. Loan out Garbutt, he's crocked tho no recall in clause. Plus the other injuries. Do we train on speedbumps like— Joc (@jocoid1) August 14, 2015