The retired striker played for both clubs and feels it will be a close game but it could be tough for Spurs.
The Premier League returns with Mauricio Pochettino’s men travelling to Old Trafford to take on a Red Devils’ side strengthened by summer recruitment.
Sheringham, who is now manager of Stevenage, had a distinguished career for club and country, playing for both of today’s sides.
He has stated that the game should be a tight affair, with his comments leaning towards a tough ask both today and over the course of the season for the White Hart Lane outfit.
"It will be a big game for both teams as they will want to get off to a great start – it’s going to be too close to call,” Sheringham told The London Evening Standard.
"What I do know is that Old Trafford will be a very tough place to go for Spurs on the first day of the season.
"There’s been a lot of talk about whether Manchester United will press for the Premier League this year, and whether Tottenham can get in the Champions League this year.
"Louis van Gaal’s made some changes at Old Trafford, and it will be interesting to see where they end up – but it’s going to be a tough season for Spurs in their attempts to break into the top four.
"I can’t split United and Spurs on Saturday – they’re both former teams of mine and I had very happy times at both so I wish both clubs all the best.”
United are expected to field a new-looking side, with summer signings such as Memphis Depay, Morgan Schneiderlin and Matteo Darmian all in the line to make their competitive debuts.
Louis van Gaal confirmed yesterday that David De Gea will miss out and as such it remains to be seen who will deputise in the home side’s goal.
Spurs have had rushed preparations for the clash, with the North Londoners playing against Real Madrid and AC Milan in Germany in midweek.