Manchester United kick off Louis van Gaal's second season in charge at Old Trafford against Tottenham Hotspur on Saturday afternoon.
Spurs took all three points from this fixture in 2012/13 and 2013/14 before falling 3-0 in March, and due to a flurry of new additions throughout the summer window, this match will now be even more unpredictable.
Ahead of the weekend's match-up, here are a few of the best Opta stats...
1 - Manchester United's defeat to Swansea at Old Trafford last season was the first time since 1972/73 that they've lost at home on the opening weekend.
3 - Nonetheless, the Red Devils are the only team to lose on the opening weekend but go on to win the title (did so in 1992/93, 1995/96 and 2012/13).
24 - Harry Kane's success will be fundamental to Tottenham's chances of victory; he won his team 24 points with his goals last season, more than any other player.
6 - Wayne Rooney has scored more goals on the opening weekend than any other current Premier League player (6). He has scored 10 goals in 15 league appearances for the Red Devils versus Tottenham.
24 - Tottenham had the youngest average starting eleven in the top-flight last season (24 years and 281 days).
5 - Spurs had gone five Premier League games unbeaten against the Red Devils (W2 D3) before losing 0-3 at Old Trafford in March.
7 - Memphis Depay scored seven direct free-kick goals last season; more than any other player in the top five European leagues or the Eredivisie.