The Spurs defender is keen to make amends and says the team has learned from past mistakes.
“It was probably our worst game of the season and their best when we last went to Old Trafford,” he said.
The 27-year old hinted that over-confidence could have been a factor in Tottenham’s dismal showing, which saw them lose 3-0 and fail to compete in any real sense, adding: “I remember we’d won a couple of games before, United weren’t in their best period and we all felt very fit and confident, but it went the other way.
“They scored quickly and we couldn’t get close to them. We certainly learned from that game but we have to do better this time.”
Spurs fans will be demanding a better performance this time around, and the signs in pre-season have been promising for Mauricio Pochettino’s men.
Signs of the Argentine's imprint have been evident and despite losses to Real Madrid and the MLS All-Stars, the performances have been encouraging.
“We’re looking sharp and we’re looking good. The manager is trying to put his ideas into the team and I think today (versus Madrid) it worked. The build-up was good and hopefully we can show that again on Saturday,” said Vertonghen.
Youthfulness was a key component for Spurs last season and Vertonghen feels the young stars will reap the benefits of the experiences gained from an eventful year.
He added: “We have a young team but everyone is a year older, a year better, a year more experienced and I have faith that we can do something there.”
A hint of uncertainty surrounds Manchester United, with a host of new signings expected to feature in their opening game and goalkeeper David De Gea omitted by Louis van Gaal - as reported by the BBC.
Spurs, in contrast, have a fairly settled first eleven - aside from Nabil Bentaleb's midfield partner and at right wing - and they will be hoping to take advantage of any growing pains in van Gaal's new-look side.