Spurs take on the Italian giants in the Audi Cup third-place play-off at 17:15 BST today.
With a trip to Old Trafford just three days away, Mauricio Pochettino will surely be looking to protect his key men in tonight's game.
Here's how we predict Spurs will line up against Milan:
With Hugo Lloris still a doubt for the United game, Michel Vorm looks set to start the season as Spurs' first choice 'keeper and while playing three games in six days is never ideal, fatigue isn't a major issue for the man between the sticks.
Luke McGee is a talent and expect to see a half-time appearance from the 19-year old.
Pochettino appears to have decided on his back four for the United game - Kyle Walker and Danny Rose flanking the Belgian duo - so this evening's encounter should see a return to action for Keiran Trippier, Ben Davies and Federico Fazio.
Nabil Bentaleb is a nailed on starter this weekend and featured for 45 minutes yesterday so his inclusion in any capacity would be surprise. Who he will play alongside is less certain however, and it makes this area of the pitch the biggest conundrum.
Ryan Mason has yet to feature in pre-season following an injury sustained on England duty so should see his first minutes. Next to him it's a toss-up between Eric Dier and Dele Alli, with whoever doesn't start likely to be in the first-team for the trip to Old Trafford.
With Alli impressing most out of the two and Dier only completing 45 minutes yesterday, it's the former Sporting Lisbon man who looks set for another outing.
The area where Spurs' lack of options becomes painfully apparent - Pochettino will struggle to both field a dangerous attack and preserve his team for the weekend.
With Harry Kane almost completing 90 minutes yesterday, and being the only senior striker worth mentioning at the club, his inclusion would be lunancy. Expect Nacer Chadli - who only played 45 minutes against Madrid - to deputise in his absence.
Behind him, Eriksen - Spurs' other key attacker - is also sure to be rested, meaning Tom Carroll should start in a familiar number ten role.
On the right flank, Erik Lamela, who failed to make any meaningful contribution against Madrid (except flattening Sergio Ramos) has arrived late to pre-season and needs minutes, so will likely be included from the off.
The left side is crying out for Alex Pritchard but his absence through injury means there's little choice but to give the talented, but raw, Josh Onomah the start.