Hugo Lloris could miss Tottenham's opener against Manchester United.
Lloris is still suffering from a wrist injury which he returned to pre-season training with, and while he is not yet officially out of the Old Trafford clash, he is rated as doubtful.
Here is a look at three key questions facing Spurs in light of his injury trouble...
Is Michel Vorm good enough to step in?
Back-up goalkeeper Michel Vorm has had limited starts for Tottenham since signing last summer, mainly featuring in the Europa League. He was dropped for the Capital One Cup Final despite featuring throughout the side's run to Wembley, perhaps with a howler against Leicester City in the FA Cup fresh in Mauricio Pochettino's mind.
Vorm is however more than just a back-up goalkeeper in terms of pedigree, impressing previously for Swansea City and earning Dutch international honours. The game against United will be a chance for him to shine and stake a claim for future opportunities.
Should Luke McGee play against Real Madrid?
With Lloris' fitness uncertain, Tottenham have the headache of still needing to play one more pre-season friendly days before the season kick-off.
It may make sense to play third choice goalkeeper Luke McGee, so to protect Vorm from injury - but the high calibre of opponent in Real Madrid, could see Pochettino keep Vorm in.
In favour of playing Vorm would be the chance to play him against top class opposition and keep him sharp ahead of the United fixture, which is a sensible approach providing he does not get hurt, which would be disastrous.
Could there be a benefit?
Transfer speculation linking Hugo Lloris to Manchester United has died down over the past month, in part due to the Frenchman's injury.
There would to nothing to ignite it quite like starring at Old Trafford in the season opener against Manchester United, with the transfer window still open.
United still have an uncertain situation over number one David de Gea, and Lloris remaining out of the spotlight could be of benefit to Spurs long-term at least.