Spurs meet the Spanish giants at 17:15 BST tomorrow, for the opening game of the Audi Cup tournament.
Ronaldo’s absence is reportedly due to him ‘suffering lower back pain’ in the club’s last training session, while Benzema has ‘overloaded his right thigh’.
The tournament will also see Bayern Munich take on AC Milan with the losers of both games meeting for a third-place play-off on Wednesday, and the winners meeting for the final later that evening.
Spurs are set for about as stern a test as it’s possible to have in pre-season and face a trip to Old Trafford just three days after their final match, raising questions over whether the club’s pre-season schedule is the most advisable.
View the full Madrid squad below:
REAL MADRID AUDI CUP SQUAD:
Goalkeepers: Keylor Navas, Casilla and Rubén Yáñez.
Defenders: Varane, Pepe, Sergio Ramos, Nacho, Marcelo, Carvajal, Arbeloa and Danilo.
Midfielders: Kroos, James, Bale, Casemiro, Modric, Cheryshev, Isco, Illarra, Asensio and Odegaard.
Forwards: Jesé, Lucas Vázquez and Borja Mayoral.