The Leeds boss made an interesting comment with regards to the 30-year-old.
Indeed, when it was suggested to him Murphy's fitness issues might affect United's transfer plans, Rosler admitted the loss of the 25-year-old to injury will be a blow - but also spoke of the loss of Rodolph Austin.
Jamaican midfielder Austin was a regular part of Neil Redfearn's first team at Leeds last term but was released this summer.
However, Rosler's comments raise an interesting issue - would the German have wanted the 30-year-old to remain with the club?
Asked how Murphy's injury might affect Rosler's transfer plans, the German told BBC Radio Leeds with a laugh: "We lost Rodolph Austin and now we've lost Luke Murphy - does that answer your question?"
Naturally, the Leeds boss will want to strengthen his midfield in the coming weeks - but might it have been stronger with Austin still at Elland Road?
The physically robust midfielder divided opinion, with many welcoming his exit and some arguing he should have remained with the Yorkshire side. But would Rosler have made sure he stayed at the club if he considers the experienced Jamaican such a loss?