The skilful forward joined the club in 2007, but spent last season on loan at Sporting Lisbon.
Portuguese winger Luis Nani, a player capable of brilliant things as well as infuriating performances, has left Manchester United for Fenerbahce this week after what was an eight-year spell at the club, and he posted an Instagram message to thank all those that helped him make his time at Old Trafford a success.
Though he won four Premier League titles, and other trophies including the Champions League, there is the feeling that Nani didn't manage to come good on the talent he had in his boots.
But there was no sense of disappointment from the Portugal international as he bid farewell, and he made sure he also showed his appreciation to the man that brought him to the Red Devils, Sir Alex Ferguson.
"I leave Manchester with many titles and many memories," Nani wrote on his Instagram. "I want to thank all the people who helped me on this journey and wish you all the luck and success!
"Thanks to all my colleagues, to all staff and management structure, thank you Sir Alex Ferguson!"
At times in his early seasons at the club, the 28-year-old looked more than capable of, if not following in the footsteps of compatriot Cristiano Ronaldo at Old Trafford, at least doing a decent imitation of him.
But too often he failed to affect the result in a big game, or would go through a spell of form that would see him drift from the first team.
It is telling that in his last three seasons at the club Nani made just 35 appearances at United, thought his recent campaign at boyhood club Sporting, where he scored a season-high 12 goals and was arguably one of the league's best attacking players, also indicated that he is someone of huge natural talent.
However, for the reported £4.25 million fee Fenerbahce have signed the player for according to the Star, it's hard to imagine him being anything but an impressive signing.
Deixo Manchester com muítos títulos e muitas recordações, quero agradecer a todas as pessoas que me ajudaram nesta caminhada e desejar-vos toda a sorte e sucesso! Obrigado a todos os meus colegas, a todo o staff e estrutura directiva, obrigado Sir Alex Ferguson! I leave Manchester with many titles and many memories, I want to thank all the people who helped me on this journey and wish you all the luck and success! Thanks to all my colleagues, to all staff and management structure, thank you Sir Alex Ferguson! Manchester'dan bir çok kupa, şampiyonluk ve harika anılarla ayrılıyorum. Kariyerimde bana destek olan tüm dostlarıma ve takım arkadaşlarıma şükranlarımı sunuyorum; hepinize bol şans ve başarılar diliyorum. Tüm takım arkadaşlarım, teknik ekip, idari kadro ve tabi ki Sir Alex Ferguson; sonsuz teşekkürler!