The Hammers take a 3-0 lead into the first qualifying round second leg against the Andorran minnows after a Diafra Sakho brace and James Tomkins goal sealed a comfortable first leg victory.
New West Ham boss Slaven Bilic watched on from the stands last time out and is expected to do so again despite travelling with the team to Andorra for a match which is already all but over as a contest.
However, it represents the perfect opportunity to give some of the club's promising youngsters a run out in a competitive fixture in difficult conditions as Lusitans play on an artificial pitch and judging by the first leg like a tackle or two.
The club announced tomorrow's team via its official Twitter feed on Wednesday night.
There will be two changes with academy starlet Cullen replacing West Ham's youngest ever player Reece Oxford in the heart of midfield while another youth player, striker Elliot Lee, replaces the injured Mauro Zarate up front.
The Republic of Ireland 'keeper plays his second game for the club after signing on a free transfer from Birmingham City. Didn't do anything wrong and looked at home in his first match last week but literally had nothing to do so was hard to judge his performance. His kicking was slightly suspect last time out so he will be looking to improve that aspect.
Homegrown starlet and boyhood West Ham fan Lewis Page is in line for his second game after an impressive performance on his debut. Page is known to like a tackle and have something of a temper so he will need to be careful in testing conditions as the Andorran minnows will be trying everything they can to claw their way back into the game.
Captain 'Tomka' looked sharp on his return to the West Ham side after a long-term shoulder injury last season and will be hoping to lead by example again after a hassle free first leg where he also grabbed a goal.
The 18-year-old is fast becoming a permanent fixture in the Hammers team despite his tender years. Didn't put a foot wrong in the first leg, was nice and positive on the ball and rightfully keeps his place.
Veteran of the side plays his 100th game for the club, a scenario that didn't seem likely last season after he was frozen out under Sam Allardyce and looked set for pastures new this summer. That may well still happen but for now is a dependable and versatile performer with bags of experience which they could need if Lusitans get a shock goal early on.
Arguably West Ham's best player last week and another who has come in from the shadows with a point to prove to new boss Slaven Bilic. There were no signs of rustiness from the winger who is another expected to leave this summer after a disappointing spell since his £10 million move from Wolverhampton Wanderers. Expect him to be involved in the goals again.
Played the holding midfield role well last time after a shaky start. Academy manager Terry Westley, who has been in charge of the Europa League squad and preparations so far, called on the young midfielder to start playing more killer passes so expect to see him looking for that defence splitting pass more often this time out.
Swashbuckling central midfielder is in the mould of the likes of Joe Cole and makes his full debut in Andorra. Brave as a lion and likes to be direct and run at defences expect to see him involved in the thick of the attacking action. He was so unlucky not to score with a brilliant curling which hit the bar in the home leg.
The vastly experienced Frenchman will give that much needed experience to help link up West Ham's attacks. One of the most skilful players on the pitch he will trouble Lusitans' left back all game long and I wouldn't bet against him getting an assist or two.
With two goals to his name already from the first leg, the exciting striker has just 18 to go to hit his season target. He could well get a few of them here as he should have scored at least a hat-trick at home. He is so valuable to the Hammers, though, so expect to see him withdrawn around half-time depending on how things pan out.
Lee finally gets his long awaited chance to show what he can do from the start of a match. A player fans have wanted to see more of for nearly a year now he was unlucky not to score in the first leg and will be itching to get that first competitive West Ham goal which will be the cue for comparisons to legend Tony Cottee.
SUBS: Spiegel (GK), Westley, Knoyle, Oxford, Nasha, Parfitt-Williams, Brown.