The Tottenham manager seemed to be looking forward to the chance to test his side in the toughest of surroundings on the opening day of the season.
The Red Devils gave Spurs one of their toughest games of last season when they beat the North Londoners 3-0 in March.
It was arguably the end of Tottenham's hopes for qualifying for the Champions League, as Spurs never got within realistic distance of fourth spot again.
But Pochettino stressed that starting against a difficult outfit like Louis van Gaal's side was a positive, emphasising that Spurs would be reflecting on their previous matches and approaching the game with confidence.
“It’s always good to play a tough side like United and it’s true that we need to learn from certain games in the past, but we need to be confident and we need to believe.
“We will work hard in pre-season to arrive at the first match at 100 per cent with the confidence to do well. With the new season comes new challenges and we are already looking forward to the start of pre-season training.”
The Argentine's comments are surely a sign that Tottenham will be looking to exact some sort of revenge for the disappointing performance and result they suffered on their last trip to Old Trafford, having won there on the two previous visits.
But United will have plans of their own to get their season off to the best possible start, so if nothing else, it looks like being an intriguing contest.