It will be the last match the club plays at the famous ground before switching postcodes from E13 to E20 as they migrate to the 54,000-seater Olympic Stadium.
A lot of the focus was on the East Londoners when the 2015/16 Premier League fixtures were released due to the impending stadium move and the fact they have made the highest profile managerial appointment of the summer, with Slaven Bilic finally arriving in England after years of speculation.
West Ham's first ever game at the Boleyn Ground was against arch rivals Millwall on September 1 1904. It drew a crowd of 10,000, the majority of whom were rewarded as West Ham ran out 3-0 winners.
The club's first ever Premier League game at the Boleyn was against Wimbledon in the opening match of the 1993/94 season on August 13th. The Hammers lost 2-0.
The ground has been graced by the likes of England World Cup winning trio Bobby Moore, Martin Peters and Geoff Hurst, Trevor Brooking, Billy Bonds and more recently Rio Ferdinand, Paolo Di Canio and Carlos Tevez, to name but a few.
Finishing against Millwall could have been fitting - given the history between the two clubs and how they came to exist from London's Docklands - but impossible as they are currently languishing in League One.
But the Hammers, who travel to Premier League runners-up Arsenal on the opening day, Aston Villa on Boxing Day and entertain Liverpool on January 2nd, will instead face Garry Monk's Swansea in the big send-off match.
The news came as something of a disappointment to many supporters who, firstly wanted it to be against their next most hated rivals Tottenham Hotspur, and secondly wanted their last home game to be the last match of the season.
West Ham United's 2015/16 fixture list (dates are subject to change)
8 Arsenal (a)
15 Leicester City (h)
22 Bournemouth (h)
29 Liverpool (a)
12 Newcastle United (h)
19 Manchester City (a)
26 Norwich City (h)
3 Sunderland (a)
17 Crystal Palace (a)
24 Chelsea (h)
31 Watford (a)
7 Everton (h)
21 Tottenham Hotspur (a)
28 West Bromwich Albion (h)
5 Manchester United (a)
12 Stoke City (h)
19 Swansea City (a)
26 Aston Villa (a)
28 Southampton (a)
2 Liverpool (h)
12 Bournemouth (a)
16 Newcastle United (a)
23 Manchester City (h)
2 Aston Villa (h)
6 Southampton (a)
13 Norwich City (a)
27 Sunderland (h)
1 Tottenham Hotspur (h)
5 Everton (a)
12 Watford (h)
19 Chelsea (a)
2 Crystal Palace (h)
9 Arsenal (h)
16 Leicester City (a)
23 Manchester United (h)
30 West Bromwich Albion (a)
7 Swansea City (h)
15 Stoke City (a)
In a HITC.com poll ahead of the fixture announcement we asked fans 'Which team would you like to see West Ham play in their last ever game at the Boleyn Ground?'
The answer was resoundingly in favour of Spurs with a 51% share of the vote. The next most popular opposition for the game was Manchester United with 14% of the vote and Chelsea in third with six per cent.
But for those feeling a little underwhelmed about the prospect of waving goodbye to Upton Park against the Welsh side, there is hope yet that it could provide a fitting spectacle.
From 50 matches between the two clubs over the years, West Ham have won 22 to Swansea's 16. That's good news for those who are desperate to see the club bow out with a win in the history books.
There have been 12 draws but more importantly the 50 matches between the pair have seen 166 goals scored at an average of nearly 3.5 a game. And West Ham scored most of them with 97 to Swansea's 69.
For those that wanted to see Tottenham play out those historic final minutes, they came pretty close with Spurs visiting on March 1st, just five home games before the end.
The Hammers don't play defending champions Chelsea until October 24th while Manchester United are the club's penultimate home game on April 23rd.
There are potentially two easier sections to the Hammers' season. Firstly between Saturday September 26th and Saturday November 28th, where seven of their nine games are against teams who finished 10th or lower last season, including newly promoted sides.
And secondly, between Saturday December 19th and Saturday February 27th where Liverpool, Southampton and Manchester City are the only real stand-out tests.
Many of the dates for the club's fixtures are subject to change depending on their progression in the Europa League, the qualifiers for which start on July 2nd.