Argentina starting XI: Romero; Zabaleta, Garay, Otamendi, Rojo; Biglia, Mascherano, Pastore; Messi, Agüero, Di María.
Uruguay starting XI: Muslera; M. Pereira, Gimenez, Godin, A. Pereira; Sanchez, Arevelo Rios, Gonzalez, C. Rodriguez; Rolan, Cavani.
Argentina will be looking to record their first victory of the 2015 Copa America as they take on Uruguay in La Serena tonight.
Gerardo Martino's men got off to a disappointing start to the competition, throwing away a 2-0 lead against Paraguay to only record a 2-2 draw.
Martino has brought Pablo Zabaleta into the side at right back, whilst Lucas Biglia replaces Ever Banega in midfield, with Lionel Messi and Angel Di Maria supporting Sergio Aguero in attack.
Uruguay weren't overly convincing themselves, beating minnows Jamaica 1-0 thanks to a Cristian Rodriguez goal on Saturday evening.
Oscar Tabarez is without Luis Suarez for the entire tournament, but Edinson Cavani will lead the line alongside Diego Rolan, with reported Leeds United target Alvaro Pereira starting at left back.
This promises to be a fierce encounter, with both sides looking to claim top spot in Group B following Paraguay's 1-0 win over Jamaica earlier tonight.