Who each of the 20 top flight clubs will face and when will become clear at around 9am on Wednesday in what promises to be an emotional season for the Hammers.
The club is moving to the 54,000 seater Olympic Stadium in Stratford next summer and will vacate the Boleyn Ground after 112 years, when the site will be redeveloped as housing, retail and leisure facilities by the Galliard Group.
A lot of attention will be on the East Londoners who have made the highest profile managerial appointment of the summer with Slaven Bilic finally arriving in England after years of speculation.
He succeeded a man in Sam Allardyce who most pundits felt had done an excellent job at the club.
Some have even tipped Bilic to struggle given his debut season is the club's last at their historic home and with the added demands of Europa League football.
So who West Ham play early on will be big news, as will who they face in the last ever match at Upton Park.
West Ham's first ever game at the Boleyn Ground was against arch rivals Millwall on September 1 1904. It drew a crowd of 10,000, the majority of whom were rewarded as West Ham ran out 3-0 winners.
The club's first ever Premier League game at their famous ground was against Wimbledon in the opening match of the 1993/94 season on August 13th. The Hammers lost 2-0.
The ground has been graced by the likes of England World Cup winning trip Bobby Moore, Martin Peters and Geoff Hurst and more recently Rio Ferdinand, Paolo Di Canio and Carlos Tevez.
But we want to know which of next season's Premier League teams would make the most fitting opposition as a send-off to one of the most historic grounds in the country.
The Hammers won't be able to play Millwall as they are not in the top flight so would a game against their next most hated rivals Tottenham Hotspur or Chelsea be an ideal last match?
Or perhaps playing against Aston Villa from whom the club borrowed its first ever kit paving the way for the Hammers' now famous claret and blue.
Maybe fans would like to see a glamour match against the likes of Manchester United, Liverpool or Arsenal. Or could a game against a smaller club like Bournemouth offer Bilic's men more chance of bowing out with a win in the history books.