The Reds have had a £10 million bid rejected by the Saints - per the BBC - as they look to strengthen an area of the squad that badly needs reinforcement, but United have reportedly rekindled their interest after Barcelona's Dani Alves signed a new contract with the newly-crowned European Champions.
After last season's disappointing return, United have substantially more to offer than Liverpool. They have Champions League football, whereas Liverpool have the Europa League, while last summer's stunning recruitment drive at Old Trafford shows they have the ability to attract marquee players without European football to offer - one only needs to look at the signing of Angel Di Maria as an example of that.
Even last summer, Liverpool were accused of not doing enough to attract top quality players, despite signing no fewer than nine new players.
The one that got away, Liverpool fans will have said, is Alexis Sanchez - who chose Arsenal over Liverpool.
The club's American owners have been accused of either not paying enough in terms of the transfer fee or not enough in wages when it comes to top targets. Fans will point to both Manchester clubs that if you have the money, then good players will arrive if you show the ambition.
Yes, Liverpool may lose out on Clyne - but if they table the bid Southampton want, and offer a compelling wage package, then they have at least done what they can within their control. Liverpool fans simply don't want any attempt to sign players 'done on the cheap'.