The Belgians currently lead their Welsh counterparts on goal difference at the top of Group B but Chris Coleman’s side gained a impressive away draw in the previous meeting between the two sides.
With the two teams both unbeaten, this is the pivotal clash in the group as Wales look to qualify for their first major tournament since the 1958 World Cup. If they do manage to qualify, they will have their two superstars to thank for some incredible match-winning displays along the way.
Ramsey and Gareth Bale have forged a terrific understanding and are the two game-changers that have enabled the Welsh to build on their solid defensive displays in the group so far. They could both slot into any side in world football with ease, a luxury which Wales have rarely had in the past.
The duo combined to devastating effect in the last qualifier as Wales defeated third-placed Israel with ease on their own patch. The Real Madrid forward in particular will be crucial to any hope they have of scoring against the side ranked second in the world.
Ramsey is excited to get the chance to link-up with Bale once again in their “biggest game for Wales.”
“It’s probably the biggest game we’ve played in for Wales with this group of players," he said.
“We’re both top of the table at the moment, so there’s a lot riding on this game. I’m looking forward to linking up with Gareth again after that performance in Israel – our understanding is good, he’s a top-quality player and it’s always nice to play with team-mates of his calibre."
“As a squad, this group is probably the best we’ve had for many years, and the effort that the boys have been putting in during this qualifying campaign has been second to none. We’ve started off fantastically, so hopefully we can get another great result and that will put us in a really good position to qualify."