Pearce is out of contract at Reading this summer and has yet to agree a new deal at the Madejski Stadium.
The likes of Leeds United and Queens Park Rangers have been credited with an interest in Pearce, but Derby are understood to be in pole position to land the Republic of Ireland international.
Despite being without a head coach since the departure of Steve McClaren earlier this month, the club are still continuing with their recruitment plans and are confident of securing a deal for Pearce.
Derby have made a new central defender one of their top targets this summer and they feel that Pearce on a free transfer would be a perfect addition to their squad for next season.
Pearce has come through the ranks at Reading and has made over 200 appearances for the Royals, but it appears that he is set to end his stay at the club this summer.