George Evans, who played all 90 minutes of the fixture at Old Trafford, is a lifelong City fan that desperately wants payback for the defeat.
"It's a local derby so it's a massive game for all of us," Evans told Manchester City's official website.
"We want to finish off the season on a win and obviously we're looking for a bit of a payback after last week.
"We want to get back to winning ways again against them - I think we actually played well in that game at Old Trafford but we just couldn't score and then we let in a couple of soft goals.
"I think we should have challenged for the title ourselves but it's not worked out that way, so we will look to show what we can do on Saturday and hopefully beat the team who did win the competition."
City's U21 side head into this weekend’s Manchester derby on the back of one of their biggest wins of the season.
It's a relief to see a Mancunian feature in a Manchester derby, albeit at U21 level. The first teams in question have such a foreign influence, due to the Premier League's high standard and financial influence, that local identity is almost forgotten about in such encounters.
There has also been a lot of talk about former Arsenal captain Patrick Vieira getting the first team job when Manuel Pellegrini eventually departs from the dugout. After an underwhelming season for the Blues, which has seen them surrender their Premier League title, the Chilean is being regularly linked with a summer ousting – per Sky Sports.