The Young Lions coach revealed his initial 27-man squad for the upcoming European U21 Championship in the Czech Republic on Wednesday, naming four of Tottenham’s promising stars in the group, including Harry Kane.
There has been tension in recent weeks between the international management and Premier League clubs over the selection of their young stars, with the likes of Everton and Manchester United not keen on their players heading to the youth tournament.
Tottenham are not one of them, though, and Southgate has praised them, saying the club is one of the best he deals with.
"Tottenham are one of our best clubs - in terms of all of the age groups - that we work with,” he said.
"A tremendous number of our good young players at every level work at Spurs and I've got a really good relationship with Mauricio (Pochettino). We're grateful for their support, as we are with all of the other clubs."
Kane in particular is an interesting inclusion, having already earned a call-up to Roy Hodgson’s full squad, scoring on his debut.
It has been an impressive season all round for the youngster, who recently won the PFA Young Player of the Year award after scoring 20 Premier League goals in his maiden campaign, despite only becoming a first-team starter towards the end of 2014.
And Southgate has praised his performances this season, saying the forward is one of his key men.
"He's had a fantastic season first and foremost and he's been a big part of our team and I think that's important for all of the group," he added.
"(It's) a great stage for Harry to show people his ability on the international stage in a top tournament and good for his development, and good for the group so we're able to take as strong a squad as we can."