The Frenchman believes England should not hold back and take their best young players to the European U21 Championship this summer.
"First of all I think Wilshere will go with the full national team and Oxlade-Chamberlain at the moment is not available," Wenger told the official Arsenal website.
"I looked this morning, since January, he has played one game, so the first challenge is for him to be fit first.
"Of course you want England to do well," he continued.
"I want Gareth Southgate to do well with his team. They have good young players.
"The situation with England is not negative with the young players, the quality has gone up, it is important now England can win a tournament like that.
"The best players who are available should go. Is Harry Kane in there? Will he be in the senior squad or the under-21s? I don't know. Why not? Wilshere has gone before."
Wilshere may have made 26 international appearances for England but repetitive injuries have delayed his progression as a footballer. In order to get that break, the Arsenal midfielder needs a consistent run of games. That could be worked on in Czech Republic as a player of his experience would go a long way in Gareth Southgate's U21 side.
It is, of course, a different situation with Oxlade-Chamberlain, who has missed out on too much football this season to be considered. While he is another player England could do with at the tournament, Southgate must also select players on form and not reputation.
Meanwhile, a questionable reference to Kane from the Arsenal boss will likely irk those close to White Hart Lane. If Wenger really wants to see England do the best they possibly can, a quiet word into the ear of Wilshere could go a long way. He's fit and ready, so there are no excuses.