The Argentine has been a key tormentor for the capital city side during his Barcelona career.
The Argentine attacker will be a key feature for the visiting side, with the four-time Ballon d’Or winner in sparkling form this year.
Messi has an enviable record against Los Colchoneros, with the South American superstar netting 22 goals in 25 games in all competitions against Diego Simeone’s men.
This record is improved in La Liga, with the scintillating forward scoring 18 goals in 17 top flight games against Atletico. He has only scored more domestic goals against one other opponent - Sevilla.
That said, much of the pain that Messi has inflicted on the capital city side came earlier in his career and the Argentine’s recent record against the outgoing champions is not as impressive.
Messi has only scored twice in the last ten meetings between Barcelona and Atletico in all competitions, while he has not scored in La Liga at the Vicente Calderon since early 2012.
That said, with the 27-year-old looking to close the two-goal deficit that he trails Cristiano Ronaldo by in the race for the Pichichi and claim the title for Barcelona, few would bet against Messi from excelling later today.