The Senegalese striker says that his side cannot afford to be complacent in either match, but also feels confident that they can secure enough points to keep themselves safe and preserve their Premier League status.
“The last two games are very important for the club, and also very important for me personally," he said.
“The last two games will not be easy, because QPR and West Ham will be wanting to win too, but Newcastle need the points so we have to work hard. I am confident everything will be OK.”
Despite Cisse's warning, Newcastle could have hardly picked two better fixtures to take in at this stage of the season.
QPR are already relegated and West Ham have been on a woeful run of form since Christmas, with the London club destined to finish in mid-table.
It means that neither have much to play for, but it will be up to Newcastle to take advantage of that situation.
To do that they will have to improve considerably on their recent displays, with ill-discipline and a poor tactical approach being exposed on a regular basis in recent weeks.