The Argentine defender has been the subject of bids from Old Trafford, but Valencia are keen to ensure he stays at the Mestalla.
Manchester United remain in hot pursuit of Argentine centre-back, Nicolas Otamendi. Having already had offers rejected, Sky Sports columnist Guillem Balague insists the Red Devils will return with another bid.
As such and according to SuperDeporte, amidst other contract renewals under negotiation, Valencia have now set improving the terms of Otamendi as their number one priority, keen to ensure he stays put at the Mestalla.
Fighting for a place in the Champions League next season, has always been the number one objective for Valencia, throughout the 2014-15 campaign. On the pitch, the club are well on track to achieve that ambition.
Off the pitch and with numerous of their leading players coveted by other clubs, the other objective is to ensure the heart of their squad remains intact, as a platform on which Valencia can build a squad truly capable of battling for La Liga, and in Europe.
Whilst talented young left-back, Jose Luis Gaya, is expected to finally pen a new deal, other important players are also scheduled for negotiations, including captain Dani Parejo, Pablo Piatti and Sofiane Feghouli.
However, given the intensity of the interest from Manchester United, it is now reported that Valencia have made their defensive 'General' Otamendi, the primary focus of the next batch of contract improvement talks.
Indeed, it is suggested that Valencia intend to pull out all the stops to ensure Otamendi stays put, which would mean greatly improved personal terms, along with a protection of their investment.
This could see Valencia try to significantly raise the current €50 million release clause, which Manchester United seem prepared to bid this summer, as they try to force through a move.
Of course, the final decision may well rest with the player and his ambitions for next season, but should Valencia clinch a place in the Champions League, it would seem more likely he'll want to stay. A bumper new deal, would also make certain that happens.