The Spanish trainer won 14 trophies in four years in the Catalan hotseat, while he also graduated from La Masia to captain the team as a player.
Guardiola has already led the Bavarian side to the Bundesliga for the second year in succession, but he knows that winning the Champions League will be the acid test.
Ahead of the return to Camp Nou, the master tactician has admitted that he has one significant object preventing him and his side from achieving glory - Lionel Messi.
The four-time Ballon d’Or winner has been in spectacular form of late, with Guardiola knowing what the Argentine is capable of more than most.
As such, the Spaniard has admitted that preventing the South American attacker from influencing affairs will be close to impossible.
"If he's on the sort of form I think he is, no defence can stop him,” Guardiola told reporters, published in Marca.
“That's impossible. There's no defensive system. He's too good.
“In light of that, we'll have to try to limit him another way: stay close to him, stop him getting the ball easily, close down the gaps... But it's still going to be tough, because you can't defend against talent."
Barcelona are still in the running for a memorable treble - something the Blaugrana have not achieved since Guardiola’s days at the club.
The winner of the clash will face either Real Madrid or Juventus in the competition final.