The 25-year-old France international is available for the Premier League encounter against Leicester City away from home at the King Power Stadium.
Sissoko missed the Magpies’ last two matches against Tottenham Hotspur and Swansea City - both at St. James’ Park - due to suspension.
The 2013 summer signing is one of the better players in the current Newcastle squad, and he is expected to slot straight back into the starting line-up.
The Frenchman seems to be excited and is looking forward to the match, as he posted the following message on Twitter earlier today:
Impatient to be back on the pitch ! Impatient de retrouver le terrain ! #NUFC— MS 7 (@ms_sissoko) May 1, 2015
Sissoko’s return from suspension is certainly going to enhance Newcastle’s chances of picking up all three points against Leicester.
John Carver’s side have lost their last seven Premier League matches and are in serious danger of suffering relegation to the Championship.
The Magpies are currently just five points above the bottom three.