With an exit looking all-but guaranteed, head coach Ronald Koeman will have to resign himself to losing Clyne, and should be doing all that he can to ensure the best deal possible for Southampton.
And that deal could be to exchange him for a current United outcast, who could fix the problems created by the England international’s departure.
Rafael, 24, has endured a torrid time at Old Trafford this term, with injury ruling him out of large parts of the season, as well as a seemingly dislike of him from Louis van Gaal.
Both Ashley Young and Antonio Valencia have been favoured in the right-back position ahead of the Brazilian, and with only a year left on his contract at the end of this season, it is likely that United will be tempted to sell him in the summer.
Southampton should make the move to secure Rafael in exchange for Clyne, with Koeman arguably the best coach in the Premier League to get the best out of him.
The Dutchman has proven that Ryan Bertrand is a Premier League class full-back despite his lack of chances at Chelsea, whilst he has a proven record of brining consistency out of all his players.
Rafael has made just 11 first-team appearances this term, although he is still a veteran of 170 games for United, despite his young age.
He has proven quality at this level, and it just seems as if all the changes since Alex Ferguson’s departure have created a lack of consistency in his play.
Koeman could be the man to bring that out of him, and Southampton could do much worse than moving for the full-back with Clyne set to depart St Mary’s Stadium.