The former Manchester United striker believes a victory for his old side at Stamford Bridge would set them up for a title challenge next year.
United take on the Blues in Saturday’s late kick-off on a fine run of form which has seen them rise up to third in the table, just a point behind second-placed Arsenal.
While Jose Mourinho’s side look destined to be Premier League champions for the first time in five years after an impressive season, there is an outside chance they could be caught if they slip up.
That is unlikely though, and focus has turned to next season, with Yorke saying a win in London would give his old side massive confidence for a title bid next year.
"There is no doubt our confidence has been boosted even further,” he said.
"If we can turn them over, it will not only help secure Champions League football but it would give the players enormous confidence for this season and the 2015-16 campaign."
Despite clearly thinking a victory is within their grasp, Yorke accepts that a win at Chelsea is still a difficult thing to achieve.
Mourinho’s side have been top of the table for the majority of the season but have slipped up on occasion, with Burnley notably having left Stamford Bridge with a hard earned point. The former forward though, says their home record is second to none and the clash will be a difficult one.
"It is a difficult place to go and get a result,” he added.
“Chelsea have come a little bit unstuck at times during the season but have shown their quality and been the best team in the Premier League so far and that is why they’re in this position. Their home record is second to none and Stamford Bridge."