Fulham will be hoping £11 million signing Ross McCormack delivers the goods against Rotherham, but they cannot make themselves mathematically safe with a win on Wednesday. Although that would put them nine points ahead of Millwall, the Lions have four games left to play against Fulham's three.
However, a win would finally give clarity to the situation and would make Kit Symons' team effectively safe if Millwall lose Saturday's trip to Cardiff or Fulham win at Blackpool, as the Craven Cottage club hold a nine-goal advantage in goal difference.
Kit Symons won't be looking that far ahead though, and while he will be mindful of Millwall's current run of two wins in the last three and only one defeat in five games, he will have a more immediate eye on Rotherham United.
Steve Evans' Millers are just two points behind Fulham and four points above the drop zone in the Sky Bet Championship, but they have lost five of the last six games.
Fulham, therefore, will see a huge opportunity to take home advantage and strike a pivotal blow in the relegation battle on Wednesday night, and help to put to bed a season that has seen them struggle to acclimatise after 13 consecutive seasons in the top flight.
A Fulham win will put them nine points clear of trouble with games against Blackpool, Middlesbrough and Norwich remaining. Therefore, despite Millwall's encouraging recent run - including a 2-0 win over Wigan on Tuesday night - there is nothing Neil Harris's men can do if Fulham take maximum points against Rotherham tonight and at already-relegated Blackpool on Saturday.
Symons will see this as very achievable, and this would put all the pressure on Rotherham as the only club that Millwall could claw back into the race, which makes Wednesday night's game at Craven Cottage a huge encounter for both clubs.