The Vicente Calderon hosts the first-leg of this much anticipated clash of the two Spanish giants, as Atletico Madrid and Real Madrid battle for Champions League progress, whilst there's plenty of motivations for either side to want victory from this encounter.
Atletico Madrid were agonisingly close to winning last year's final, only for a stoppage-time equaliser from Real Madrid, who then demolished their rivals in extra-time, laying their hands of the famous trophy.
However, in domestic competition and particularly this season, Simeone's side inflicted a punishing 4-0 defeat on Ancelotti's men in La Liga. One they'll be just as keen to avenge.
Simeone has opted to go with an attacking 4-4-2 formation, which sees Koke and Arda Turan playing on either flank, with the striker pairing of Griezmann and Mandzukic.
Ancelotti fields arguably his strongest eleven, but for the absence of Pepe in the heart of defence, who is on the bench. The fearsome 'BBC' trio in attack all play, with Gareth Bale recovering fully from his recent foot injury.
Atletico Madrid Starting XI:
Oblak; Juanfran, Miranda, Godin, Siqueira; Arda Turan, Mario Suarez, Gabi, Koke; Griezmann, Mandzukic.
Moya, Gamez, Gimenez, Tiago, Raul Garcia, Saul Niguez, Fernando Torres.
Real Madrid Starting XI:
Casillas; Carvajal, Varane, Ramos, Marcelo; Kroos, Modric, James; Bale, Benzema, Cristiano Ronaldo.
Keylor Navas, Pepe, Khedira, Arbeloa, Jesé, Isco, Illarramendi.