The best known is undoubtedly Sir Geoff Hurst, the only man to score a hat-trick in a World Cup final and scorer of 242 goals in 500 games for the Hammers. But after a hugely successful spell at the Boleyn, Hurst moved on to Stoke for the princely sum of £80,000 where he would spend three seasons and score 30 goals in 108 games.
Another who enjoyed relative success at both clubs is winger Matty Etherington, who retired earlier this season after failing to secure a club for the 2014/15 campaign following his release from Stoke.
Etherington, who scored 16 goals in 165 games for the Hammers and came close to helping the side win the 2006 FA Cup, moved to Stoke in 2009, going on to score 13 goals in 152 games for the Potters.
On the whole Etherington will be remembered fondly by Hammers fans, but sullied his reputation somewhat by diving to win a crucial penalty in Stoke's FA Cup win over the Irons under Avram Grant in 2011.
Kevin Keen is another who will be fondly remembered by both sets of supporters having enjoyed success in London and Staffordshire. Other players to have pulled on both the claret and blue and the red and white stripes in the past include Lee Chapman, Steve Banks, Paul Allen, Frank Richardson, Lawrie Leslie, Bob Dixon and Nicky Morgan.
More recently fans' favourite Abdoulaye Faye was a star for both while Clive Clarke, Luke Chadwick, John Carew, Henri Camara, Danny Collins and Matthew Upson complete the list.
Lou Macari managed both clubs, with an ill-fated spell at West Ham and two spells in charge of the Potters.