Manchester United will not have all of their top three strikers available to face Manchester City this weekend.
Van Persie has not played at all since the loss to Swansea City in February, and although he is back in training, manager Louis van Gaal has told MUTV that he will not feature in the Manchester derby.
Wayne Rooney is the most likely to start, having overtaken the Dutchman as United's top scorer in his absence.
Radamel Falcao remains a possibility, keen to make an impact having missed the derby at The Etihad with an injury.
The Colombian has seven games left in which to make an impact before his loan spell from Monaco expires.
Angel di Maria, Juan Mata, Ashley Young and Ander Herrera are all fit, leaving manager Van Gaal with further selection dilemmas.
Luke Shaw is also back, also giving the boss a choice between himself and Daley Blind for the left-back position.
United head into the game full of confidence having won three games in a row, climbing above City for the first time in 2015.