The former Seattle Sounders star, who impressed for the US at the World Cup, could fill in for Kyle Walker in Saturday's match against Aston Villa.
With doubts surrounding Kyle Walker's fitness ahead of Tottenham's game with Aston Villa on Saturday, there is a chance that rapid, young US fullback DeAndre Yedlin may be involved with a first team squad lacking any other right-sided options in defence.
Earlier on in the season, right-back was a position of real concern for Mauricio Pochettino and the White Hart Lane faithful.
With Walker's pelvic problem ruling him out for much of the first half of the season, the Argentine tried three or four different players at fullback, all with varying levels of success.
Youngster Eric Dier started the season there, despite preferring to play in central defence, and though he had some early moments of promise, there were major errors too, notably as Sammy Ameobi scored just seconds into the second half as Newcastle won at White Hart Lane.
Vlad Chriches has also been tried in that position, and was brought on for the second half at Turf Moor, but is clearly not a favourite of the former Southampton boss, while regular reserve right-back Kyle Naughton endured another frustrating and error-strewn campaign, before being sold on to Swansea in January - where he has looked much more confident and capable in all fairness.
It very much looked like Yedlin's early January arrival, after he had been scheduled to arrive in the summer, led to Pochettino sanctioning the exit of one first-team player in Naughton, and left Spurs fans excited at the prospect of seeing an attacking fullback rumoured to be one of the quickest around.
However, that debut never came, as Yedlin suffered some niggling injuries and was gently introduced to life at a top English club rather than being thrown in, while Walker kept fit if a little temperamental in form.
But with the first-choice Spurs right-back unable to shake off a foot injury before half time of the draw with Burnley, it may be Yedlin who is given an opportunity to make his long awaited debut for the North Londoners if the ex Sheffield United man fails to improve by the weekend.
The 21-year-old Yedlin has already featured four times for the US national team since his move, more times than he has turned out for the Spurs Under-21 group, but after doing well in the 0-0 Under-21 draw at Chelsea on Monday, Pochettino may give the fullback a chance in what, on paper, looks a winnable match against Aston Villa on Saturday.