Defoe has played in a number of derbies over the years, and he has told his teammates that they need to pick up all three points from the Premier League clash.
“I’ve said to the boys you’ve just got to prepare 100% because there’s no excuses,” the 32-year-old told The Chronicle.
“You can’t go into the game thinking you’re a little bit tired. If you give everything and you don’t end up winning the game – any game – you can say, I couldn’t do any more.
“The way the lads have trained this week, the way we’ve prepared has been spot on. All the lads have been going into the gym after training. Hopefully we can take that into the game.”
Defoe will be a key player for Sunderland against Newcastle, as the Black Cats look to return to winning ways in the Premier League.
The former West Ham United and Tottenham Hotspur striker has been struggling for goals since his move to the Black Cats from Toronto FC in the January transfer window.
The veteran striker was expected to solve Sunderland’s goalscoring problems, but in nine Premier League appearances so far, he has scored only two goals.
Defoe has created only three chances in those matches, and has a pass accuracy of 77% and a shot accuracy of 54%.
However, the international break will have refreshed Defoe and his Sunderland teammates, who will be determined to win the Tyne-Wear derby and enhance their chances of survival in the Premier League.