The Brazilian was on the receiving end of plenty of heavy tackles from the Chileans.
There seemed little 'friendly' in nature during the heated duel, with plenty of heavy tackles and challenges from both sides, leading to English referee Martin Atkinson dishing out five yellow cards for Brazil, plus two for Chile.
Combative Chile midfielder Guy Medel, never one to hold back from getting stuck in, crunched a few times with Neymar, as the pair tussled for the ball.
One such incident saw Medal appear to stomp on the lower leg of Neymar, whilst he also lashed out with his boot, catching the knee of the Chile midfielder.
Disgruntled with how heavily the challenges were flying in his direction from the Chile players, Neymar later vented his frustrations in the mixed zone after the final whistle, critical of referee Martin Atkinson and feeling he perhaps should have been afforded better protection.
Indeed, Neymar went so far as to suggest the game was more like a UFC bout, as Brazil and Chile slugged it out, though his side had the last laugh, thanks to a single winning goal from Roberto Firmino, in the 72nd minute.
Despite the heavy nature of the challenges between the two sides, Barcelona fans will be relieved to know that aside from a little wounded pride, perhaps, Neymar came out of the game relatively unscathed.
Having featured for Brazil during this latest international break, his attention will now be firmly fixed on getting himself back in action with Barcelona, as they attempt to win a treble of silverware this season, in La Liga, the Copa del Rey and the Champions League.