Lloris had to go off early in the tie, and Michel Vorm did not have a good game as his understudy.
Spurs were reliant on a Harry Kane hat-trick to lead them to victory, and many will be hoping that the French stopper is not too seriously injured, so he is back following the international break for the last weeks of the season.
However, there could be a benefit to Lloris missing a large portion of game-time, with the weaknesses in the Lilywhites squad highlighted for all to see.
Head coach Mauricio Pochettino has been receiving a lot of praise this term for the work he has done at White Hart Lane, much of which is deserved. However, the former Argentine centre-half has been praised for making the Tottenham defensive line much better than they actually are, and the loss of Lloris will show this up in the coming weeks.
The French captain is undoubtedly one of the top goalkeepers in the Premier League, and he has the ability to single-handedly win games on his own. However, this ability generally takes much of the pressure off the defenders in front of him, when their mistakes go unpunished.
With Vorm in goal, these mistakes were capitalised on by Leicester, and it showed the lack of defensive solidity in the Spurs ranks.
Kyle Walker and Danny Rose are not natural defenders, and it shows, as they are often found out of position and have to utilise their pace to make up for numerous errors. Even the senior figure of Jan Vertonghen has been far below his best this term.
Eric Dier can be forgiven due to his age, while Federico Fazio has seemingly been banished from the first-team by Pochettino.
For all the talk of Spurs needing to strengthen in the summer, the defence is seemingly the one area that is often overlooked. However, the North London club have a defence that is better than only the three lowest-ranked clubs and Newcastle United - and that is with the brilliant Lloris playing.
It is never good to see a player go down injured and potentially be missing for an extended period of time. However, for Spurs, Lloris missing a chunk of action could play into their hands, and could be a catalyst that means they strengthen some vital areas before the start of next season.