The La Liga duo are separated by just one point at the top of the Spanish top flight, Barcelona leading the way following Madrid’s indifferent form of late.
Los Blancos head into the encounter having won only two of their previous five matches in all competitions, including an embarrassing 4-3 home defeat to Schalke in the Champions League.
The Spanish media have not been impressed with Carlo Ancelotti’s men of late, with former Spurs star Gareth Bale bearing the brunt of heavy criticism.
The Wales international was idolised at White Hart Lane but, despite what he achieved in Madrid last season, in recent weeks he has had to endure whistles from his own supporters at the Santiago Bernabeu.
Barcelona, on the other hand, can do little wrong at the minute and a marvellous run of 17 victories in 19 matches has left the Catalans potentially on the verge of another treble success.
Lionel Messi has been out of this world, taking his La Liga tally to 32 - past Cristiano Ronaldo’s 30 – as well as contributing another 14 assists.
Madrid’s task couldn’t be bigger, but that hasn’t dampened the mood in the Spanish capital, and the return of Modric and Sergio Ramos is undoubtedly a massive boost.
Here are former Spurs duo Bale and Modric preparing on Friday for the biggest game of the season to date: