The currently injured forward was at Burnley from the age of 11.
Last season it looked as though Rodriguez was making a late surge to be part of the England team for the World Cup in Brazil.
The former Burnley star was in sensational form, scoring 17 goals by the end of March, when disaster struck.
He suffered a serious knee injury against Manchester City on the 5th April last year, nearly a year ago, and has not played since. The England international was originally scheduled to be back before the New Year but he has suffered setbacks in his recovery and at this rate, it will be a surprise if he makes it back before the end of the season.
Today there is no doubt he would love to be in the Southampton team as they take on his former club Burnley.
Rodriguez is Burnley born and raised and played for the club from the age of 11. He left in 2012 to join Southampton for a fee reported by the BBC to be in £7 million range.
He has Tweeted on the fixture this afternoon as he gets set to reluctantly watch the game.
Jay Rodriguez (@JayRodriguez9) March 21, 2015
Burnley fans will likely be pleased he is missing today, but they and Saints fans will be wishing him a swift return to action.