The former Arsenal man isn't expecting the Premier League champions to overcome a first leg defeat in the last-16 of the Champions League.
The Premier League champions head to the Nou Camp looking to overturn a 2-1 loss at the Etihad, needing to score two goals or more in order to qualify for the last eight of the competition and better the efforts of domestic rivals Arsenal and Chelsea.
Despite the odds being stacked against them, City remain in with a chance of victory after Lionel Messi missed a late penalty in the first leg, which would have arguably put the tie beyond them.
Nicholas though, doesn’t give City much hope despite their side being full of world-class talent such as Sergio Aguero and Yaya Toure.
"You’ve always got hope with quality players,” said Nicholas.
“[However] Sergio Aguero has struggled with his fitness, while Edin Dzeko and Yaya Toure have been cold. Toure needs a lot of the ball and he’s not going to get that in Barcelona.”
Barcelona not great defensively
The former footballer turned pundit also believes that City could have some success given the fact that the La Liga leaders aren’t the strongest defensively, with set pieces likely to prove vital in the pursuit of progression.
However, he admits that Barca are a side on a good run of form at the moment, with attacking talents Lionel Messi, Luis Suarez and Neymar improving all the time, while City defender Vincent Kompany has never enjoyed coming up against former Liverpool man Suarez.
“Barca aren’t great defensively and you can definitely get at them and set-pieces with be vital,” added Nicholas.
“However, they’re on an up at the moment with Lionel Messi back on form and Luis Suarez improving. Vincent Kompany doesn’t like playing Suarez, he never has. It will be a foreign farewell for English clubs in the Champions League.”