The Saints have had an outstanding season so far, but their impressive performances under Ronald Koeman will no doubt attract plenty of interest in their players.
Last summer, they lost Calum Chambers, Dejan Lovren, Luke Shaw, Adam Lallana and Rickie Lambert, and Koeman faces another summer of uncertainty.
The Mirror report that Southampton have now offered right back Clyne a new contract worth £45,000-per-week in a bid to prevent a bid from Manchester United when the transfer window re-opens.
Former Crystal Palace defender, 23, has established himself as one of the Premier League's top full backs, and will surely be a key part of Roy Hodgson's England side in the future.
His consistently excellent displays in a mean Saints defence have unsurprisingly attracted interest from other clubs, with the Mirror believing Manchester United are leading the way as a replacement for Antonio Valencia, who is a right winger playing as a right back.
The Mirror also report that Chelsea are also considering a move for Clyne, and that the Saints will also make a last-gasp offer to convince Morgan Schneiderlin to stay on the South Coast, with the Frenchman also a reported target for Premeir League clubs.