The ex-Chelsea striker leaves a side that is in relegation trouble in Serie A as they currently sit four points adrift from safety with 12 games to go.
The news from Italy inevitably got some reaction from fans of his former clubs in England. Zola is fondly remembered at Stamford Bridge as a Chelsea legend for his exploits in front of goal, and he did have his moments as manager of West Ham and Watford.
During his time with the Hammers they finished in ninth place in his first season in charge before they struggled the following season, and avoided relegation to the Championship by just five points in 2009/10. He was relieved of his duties at the Boleyn Ground shortly after that season had finished.
He took over at Watford in 2012 and memorably took them to the Championship play-off final in 2013, only for them to lose out in extra time to Crystal Palace like at West Ham the following season wasn't as fruitful as he resigned the following December with the side 13th in the league.
Some fans are not surprised Zola has had another unsuccessful spell in management, others think he has some good footballing ideas which have yet to come to fruition, while a couple of Chelsea fans wouldn't mind seeing him back at Stamford Bridge in some capacity.
Here is a sample of some of the reaction on twitter:
Zola fired by Cagliari. Neat guy, bright ideas. But #WatfordFC supporters saw the limits to those ideas up close.— Lou Whiteman (@louwhiteman) March 9, 2015
Stop sacking Zola you monsters.— Michael (@Regista_Michael) March 9, 2015
Feel sorry for former WHUFC boss Gianfranco Zola who's been sacked by Cagliari after just 11 games. Can't expect him to win without Ibarbo!— Spencer FC (@SpencerOwen) March 9, 2015