Saturday's encounter is Leeds' third visit to the DW Stadium in the league and they have yet to record a win or even score a goal.
The first ever league encounter between the two clubs was in 2004/05 when Paul Jewell steered the Latics to a second successive promotion. Wigan triumphed 3-0 at the then JJB Stadium, having won 2-0 at Elland Road earlier in the season.
It was last season when the clubs met again at the re-named DW Stadium, and a first half Martyn Waghorn goal proved decisive in a low-key end of season encounter.
So Leeds travel across the Pennines in the hope of recording a first win at the ground and scoring a first league goal. They will be buoyed by Wednesday night's 2-1 win at home to play-off chasing Ipswich Town, but manager Neil Redfearn is also mindful of Wigan's current form in the Sky Bet Championship.
Malky Mackay's men have won their last two games, both on the road at Blackpool and Norwich. However, they have won only two games at home all season, the last one coming at the end of August, and Redfearn is mindful of that run coming to an end some time.
Redfearn told the Yorkshire Evening Post: “Wigan are due to win one at home and we’ve got to make sure it’s not against us. We’ve got to be right on it. I think it’s going to be a tough game. I think the surface is going to make it difficult and Wigan are fighting for their lives and doing it well. They’ve picked up their results and particularly on their travels they have been excellent."
Leeds have won at Wigan in the past. The first ever encounter between the two clubs was in the FA Cup in 1987, when Leeds won 2-0 at Wigan's original ground Springfield Park. The two clubs also met at the current stadium in the FA Cup in 2006, when Rob Hulse netted an equaliser for Leeds in a 1-1 draw.