The former Arsenal defender has tipped Chelsea to win the first trophy on offer this season.
In his Q&A session with the Daily Mail, Keown predicted Jose Mourinho to lift the trophy for a third time with Chelsea, despite their last meeting on New Years' Day resulting in a 5-3 victory for Tottenham.
The Spurs side features several players who are still developing in the form of Ryan Mason, Nabil Bentaleb and Harry Kane, who have all started to experience regular first team football within the past 18 months.
Keown said: "Tottenham’s 5-3 win at White Hart Lane this season was astonishing, but when you get to a final it’s different. It’s where the inexperience of the likes of Kane, Ryan Mason and Eric Dier may be a problem.
"There’s know-how in Chelsea team. They know how to to dictate the pace of the game and play it at their own pace.
"Tottenham will be confident after their victory on New Year's Day, but this is not at home - it’s at Wembley.
"They’ll have to put the pressure and fanfare of the final to one side and concentrate on the game. Chelsea have done all this before."
Spurs will inevitably feel that they have Chelsea's number after the way they played against them at White Hart Lane, but this Chelsea side does have a lot of experience when it comes to winning big games and showpiece events, as very few of their regulars don't have a major honour to their name from their career either at Stamford Bridge or elsewhere.
One thing Spurs will definitely have on their side is a hunger to win their first major silverware in seven years, when they beat Chelsea in extra time to lift the same trophy when Juande Ramos was in charge back in 2008.
Experience could be a factor when it comes to managing certain periods of the game, and Head Coach Mauricio Pochettino will hope to channel the hunger and energy into a positive performance that troubles Jose Mourinho's side.
Chelsea go into the game as favourites but Tottenham will be encouraged by their performances of late, but it will be interesting to see what effect the side's Europa League exploits have on the team, compared to Chelsea who have had a clear week of preparation.