Barcelona forward is on a barren run against the England 'keeper - at club level, at least.
And, while the fan abuse won't bother him, one person will certainly be looming large in his mind - City 'keeper Joe Hart.
That's because the giant goalie has the hoodoo sign over the Barcelona number nine, usually coming out on top when the pair meet.
In fact, until Suarez's devastating brace against England at the World Cup, he'd only found a way past Hart once in six previous meetings.
Even with that double to bolster his record, one of the Premier League's most rampant forwards of all-time has struggled when facing Hart.
In seven face-offs, he has as many yellow cards as he does goals - three.
And Hart has stopped Suarez scoring in five of their seven meetings.
Even last season, when the then-Liverpool man was finding the back of the net for fun, Suarez was unable to score against City and Hart in either league fixture.
While Brendan Rodgers' men seemed to be hurtling towards the title, Liverpool saw off City 3-2 in an enthralling Anfield clash. But the superstar leading the line was strangely missing in action that day.
His only Liverpool goal against Hart came in August 2012, in a 2-2 draw. He was also booked in that tie.
With a surprisingly meagre goal return since joining Barca in the summer - mustering just four league goals compared to Lionel Messi's 26, and Neymar's 17 - Suarez might just be anxious about his odds of netting against his old nemesis tonight.