Liverpool defender said he enjoyed playing against his former side.
The centre-back has had a difficult adjustment to playing for Liverpool, and hadn't previously been selected to start a Premier League game in 2015.
That changed against the Saints, with manager Brendan Rodgers bringing him into the side with no ill results. Lovren played his role in helping Liverpool keep a clean sheet in an entertaining 2-0 win.
His selection was not sprung upon him at the last minute either, with the defender telling Liverpool's official website that he had bee anticipating playing at St Mary's.
He said: "I found out in the last couple of days that I would play. I was always ready to play and come in. Of course, it was a special moment to play against my ex-team - especially after the win, I'm happy.
"It was an amazing win. It was a tough game for us and we knew when we arrived here that it would be difficult. It's a massive three points for us, now we're a step closer to the top four."
Lovren's departure from Southampton in the summer came in acrimonious circumstances, with the defender described by the Daily Echo at the time as attempting to force a move.
He got his way in the end and Southampton had so far got the better end of the deal, with Lovren failing to command a regular place at Liverpool and the Saints defence arguably even stronger this season under Ronald Koeman's management.
At the weekend however it was the £20 million summer signing who reversed the trend, and he will hope this can be a turning point in his season.