The former Arsenal centre-back feels the Frenchman's know-how will prove crucial.
But Keown feels Wenger's experience in the same situation of previous years will be a huge boost for Arsenal when it comes to beating the competition.
"Arsenal have a manager with great know-how when it comes to coping with that final furlong. There are a lot of games coming up," the former Arsenal defender said during a 'Tackle Keown' session on the Daily Mail website.
However, the Gunners icon feels the north London side's FA Cup clash with Manchester United will prove a hindrance in the race for a Champions League place.
Arsenal have been drawn against United in the quarter-finals of the knockout tournament and Keown is wary Wenger will have to rotate his squad in the build-up to such a huge fixture.
He added: "I don’t think it helps Arsenal playing Manchester United in the FA Cup, it’s a huge game. There could be some adjustments of the squads leading up to that."
The Gunners travel to Crystal Palace at 3pm this Saturday afternoon for what could prove to be a serious test of their top-four credentials. Alan Pardew's side have proven a strong outfit at Selhurst Park in recent weeks, although Liverpool's Cup win over the Eagles was the perfect example for how Wenger's men should go about their business.